Luminesce™ Anti-Aging Serum Clinical Trial

 

Introduction:

Luminesce™ is an anti-aging skin serum formulated with patent-pending technology for the delivery of key growth factors found in natural human skin.  These natural human growth factors include TGF- (1-3) [Transforming growth factor beta], PDGF [Platelet derived growth factor], GM-CSF [Granulocyte-macrophage colony-stimulating factor], and Interleukins (IL3, IL6-8).  As we age, the production of these growth factors within skin is reduced, and leads to wrinkling and thinning of the skin.

 

By re-introducing these factors through daily application of Luminesce™, damaged skin cells may be repaired, and skin tissue regenerated.  Thus the following study was conducted to test the effectiveness of Luminesce™ on facial skin appearance, texture, firmness, color, and wrinkles.

 

Methods:

Eighteen women, ages 36-55 (Avg. 47 yrs. old) used Luminesce™ twice daily for 90 days.  A mild facial cleanser (Cetaphil Gentle Skin Cleanser) and daily lotion with SPF (Cetaphil daily facial moisturizer, SPF 15) was supplied to all participants to eliminate variability in daily regimens as well as skewing of results due to outside product effects.  Luminesce™ was applied to the face after cleansing with facial cleanser, and was then followed by application of moisturizer.  Baseline pictures and skin evaluations were taken at the start of the study.  Patients’ skin was assessed clinically by a registered nurse/aesthetician, as well as by individual responses to a comprehensive questionnaire.  Close-up pictures were taken via a Polaroid Macro 5 SLR camera, and focused on left and right eyes (crow’s feet areas), forehead regions, and mouth/labial fold areas.  Participants returned for evaluations and pictures at 30, 60, and 90 days post-baseline measurement.  Throughout the study, four women dropped out due to noncompliance with regimen.   

 

Results: 

In general, patients saw a 10-20% improvement in skin features within four weeks of use with Luminesce™, which improved another 10% after 12 weeks of use (see Table 1).  The most notable improvements observed by the esthetician and patients were plumper, firmer, and brighter skin, improvement in wrinkles around the nasal labial fold lines, and significant improvement in skin dryness in patients with previous histories of dry skin.  Three patients incurred acne outbreaks due to application of Luminesce™, and one patient with acne prone skin experienced a decrease in cystic acne outbreaks with use of Luminesce™.  Luminesce™ was also found to eliminate the appearance of rosacea in the two women presenting rosacea in this study.

 

Overall, an average 50% of the participants saw mild improvement, 30% observed significant improvement, and 20% experienced little to no improvement to skin after 90 days use of Luminesce™ (See Figure 1).  There was no correlation between improvement outcome and the age of the patient.  When asked to compare Luminesce™ to other anti-aging products, 50% of the patients found Luminesce™ to be moderately more effective, 30% believed Luminesce™ to be far more effective, 14% found Luminesce™ to work the same, and 6% thought Luminesce™ was slightly less effective in improving skin appearance compared to other products.  Luminesce™ was found to have good absorption into the skin, easy application, and did not irritate the skin.  Patient complaints about Luminesce™ included that the formulation was too runny, had a bad odor, and did not come out of the pump well.  Participants were further questioned at end of the study as to whether they would purchase and use Luminesce™ in the future.  57% of the participants confirmed that they would continue the Luminesce™ regimen, 36% would not buy Luminesce™, and 7% said they may buy Luminesce™, but it would depend on the cost.  The overall reason for not continuing use of Luminesce™ was the lack of observed results in comparison to the high cost of the product.

 

 

 

Table I:  Facial Skin Improvements from Baseline

 

SKIN FACTORS

  

 

Improvement (% ± SD)

 

30 days

60 days

90 days

Overall Appearance

10 ± 10

20 ± 10

20 ± 10

Wrinkles Reduced

10 ± 10

10 ± 10

20 ± 10

Crows Feet

10 ± 10

10 ± 10

20 ± 10

Mouth/Nasal labial folds

10 ± 10

20 ± 10

20 ± 10

Color/Tone

10 ± 10

10 ± 10

20 ± 10

Smoothness/Texture

10 ± 10

20 ± 10

30 ± 10

Firmness

20 ± 20

20 ± 10

30 ± 10

Dryness

10 ± 20

20 ± 20

20 ± 20

Photo-damage

10 ± 10

10 ± 10

10 ± 10

 

 

 

 

 

 

 

 

 

 

 

 

Figure 1: Average Effects of Luminesce™ on Skin Overall Appearance

 

Figure 2: Comparison of Luminesce™ to Other Products

 

 

Figure 3: Continued Use of Luminesce™ 

 

 

 

 

Side Effects:

The only side effect experienced with Luminesce™ in this study was the development of acne in three patients.  Small, closed comedones and single pimples appeared in the chin, forehead, or cheekbone area of these patients.  Use of Luminesce™ was decreased to once per day for these women, and over time their outbreaks disappeared.  There were no other side effects or skin reactions experienced with use of Luminesce™ over the 90-day trial.

 

Conclusions:

In summary, 80% of the participants in this study saw some type of improvement to their skin appearance by use of Luminesce™.  Significant results, however, were observed in only 30% of the patients.  It is believed that the lack of significant findings is due to the inability of the growth factors present in Luminesce™ to diffuse through the epidermal layer of the skin and into the dermal layer.  This theory is supported by the fact that patients with thick, oily skin types had little to no observable improvement to their skin. Future formulations of Luminesce™ should increase the viscosity of the product, include penetration enhancers to facilitate the diffusion of growth factors into the skin, and should have a neutral or more pleasant odor.  Further study is also necessary to confirm the findings of this trial, demonstrate whether more significant results can be obtained from an enhanced formulation, and variables should be blinded to study facilitators for unbiased analysis.

 

創作者介紹

Imelda (之樺) Jeunesse Global; 婕斯環球

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